PUBLICATIONS

2022

The obesogenic and glycemic effect of bariatric surgery in a family with a loss-of-function mutation in melanocortin 4 receptor.

Ronit Grinbaum#, Nahum Beglaibter, Stella Mitrani-Rosenbaum, Lee Kaplan, Danny Ben-Zvi#.

Metabolites. 12(5); 430

Physically interacting beta-delta pairs in the regenerating pancreas revealed by single-cell sequencing

Eran Yanowski E, Nancy Yacovzada, Eyal David, Amir Giladi, Diego Jaitin, Lydia Farack, Anat Egozi , Danny Ben-Zvi, Shalev Itzkovitz, Ido Amit, Eran Hornstein.

Molecular Metabolism. Jun 60 (2022)

Generation and characterization of a mouse model for one anastomosis gastric bypass surgery

Samir Abu-Gazala*, Michael Bergel*, Yhara Arad, Liron Hefetz, Shira Azulai, Aaron Baker, Arnon Haran, Hadar Israeli, Doron Kleiman, Itia Samuel , Uria Tsubari, Anna Permyakova, Joseph Tam, Rachel Ben-Haroush Schyr#, Danny Ben-Zvi#.

Americal Journal of Physiology-Endocrinology and Metabolism. May 1;322(5):e414-e424

Maternal antagonism of Glp1 reverses the adverse outcomes of sleeve gastrectomy on mouse offspring

Liron Hefetz, Rachel Ben-Haroush Schyr, Michael Bergel, Yhara Arad, Doron Kleiman, Hadar Israeli, Itia Samuel, Shira Azulai, Arnon Haran, Yovel Levi, Dana Sender, Amichai Rottenstreich, Danny Ben-Zvi.

JCI Insight. 7(7) e156424

 

Attention-Deficit Hyperactivity Disorder and Obesity – A National Study of 1.1 Million Israeli Adolescents

Pinhas Hamiel O, Bardugo A, Reichman B, Derazne E, Landau Z, Tokalty-Latzer I, Lerner-Geva L, Rotschield J, Tzur D, Ben-Zvi D, Afek A, Twig G.

Journal of Clinical Endocrinology and Metabolism. Mar 24;107(4):e1434-e1443 

2021

Sleeve gastrectomy suppresses hepatic glucose production and increases hepatic insulin clearance independent of weight-loss

Rachel Ben-Haroush Schyr#, Abbas Al-Kurd, Botros Moalem, Anna Permyakova, Hadar Israeli , Aya Bardugo, Liron Hefetz, Michael Bergel, Arnon Haran, Shahar Azar, Itia Magenheim, Joseph Tam, Ronit Grinbaum, Danny Ben-Zvi#.

Diabetes. . Oct; 70(10) 2289-98 

Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study

Shira Azulai, Ronit Grinbaum, Nahum Beglaibter, Shai Meron Eldar, Moshe Rubin, Shai Carmi, Rachel Ben-Haroush Schyr, Orly Romano-Zelekha, Danny Ben-Zvi.

Journal of Clinical Medicine. 10(12), 2724

Structure reveals the activation mechanism for MC4 receptor to initiate satiation signaling

Hadar Israeli*, Oksana Degtjarik*, Fabrizio Fierro, Vidicha Chunilal, Amandeep Kaur Gill, Nicolas J Roth, Joaquin Botta, Vadivel Prabahar, Yoav Peleg, Li F Chan, Danny Ben-Zvi#, Peter McCormick#, Masha Y Niv#, Moran Shalev-Benami#. 

Science. May 21 372(6544) 808-814 

Sleeve Gastrectomy is associated with a greater reduction in Plasma Liver Enzymes than Bypass Surgeries: A Registry Based Two-Year Followup Study

Shira Azulai, Ronit Grinbaum, Nahum Beglaibter, Shai Meron Eldar, Moshe Rubin, Rachel Ben-Haroush Schyr, Orly Romano-Zelekha, Danny Ben-Zvi.

Journal of Clinical Medicine. 10(5) 1144 

a-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

Weih-Hua Chiu, Lora Kovacheva, Ruth E Musgrove, Hadar Arien-Zakay, James B Koprich, Jonathan M Brotchie, Rami Yaka, Danny Ben-Zvi, Menachem Hanani, Joschen Roeper, Joshue A Goldberg.

Science Advances, Mar 10;7(11) (2021)

 

2020

Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARa dependent

Shahar AzarShiran UdiAdi DroriRivka HadarAlina NemerovskiKiran V VemuriMaya MillerDana Sherill-RofeYhara AradDevorah Gur-WahnonXiaoling LiAlexandros MakriyannisDanny Ben-ZviYuval TabachIddo Z Ben-Dov , Joseph Tam.

Molecular Metabolism. Sep 26(42) (2020)

Localized Antileptin Therapy Prevents Aortic Root Dilatation and Preserves Left Ventricular Systolic Function in a Murine Model of Marfan Syndrome

Sudeshna FischNoa Bachner-HinenzonOffir ErtrachtLiang GuoYhara AradDanny Ben-ZviRonglih Liao and Jacob Schneiderman.

Journal of the American Heart Association. May 18;9(10):e014761. (2020)

 

2019

Intestine-Specific Overexpression of LDLR Enhances Cholesterol Excretion and Induces Metabolic Changes in Male Mice

Luca Meoli L, Danny Ben-Zvi, Courtney Panciotti, Stephany Kvas, Palmenia Pizarro, Ricardo Munoz, Nicholas Stylopoulos.

Endocrinology. en.2018-00098, (2019)

2018

Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction​

David Kain, Amos Simon, Abraham Greenberg, Danny Ben-Zvi, Boris Gilburd, Jacob Schneiderman.

PLoS ONE, Oct 12;13(10):e0203902. doi: 10.1371/journal.pone.0203902. (2018)

Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species

Danny Ben-Zvi#, Luca Meoli, Wasif Abidi, Eireni Nestoridi, Courtney Panciotti, Erick  Castillo, Palmenia Pizzaro, Eleanor Shirley, William Gourash, Christopher Thompson, Ricardo Munoz, Clary Clish, Ron Anafi, Anita Courcoulas, Nicholas Stylopoulos#.

Cell Metabolism. Aug 7;28(2):310-323.e6 (2018)

... and featured in Science 

Sleeve gastrectomy improves glycemia independent of weight loss by restoring hepatic insulin sensitivity

Samir Abu-Gazala*, Elad Horwitz* , Rachel Ben-Haroush Schyr, Aya Bardugo, Hadar Israeli, Ayat Hija, Jonathan Schug, Soona Shin, Yuval Dor, Klaus Kaestner# and Danny Ben-Zvi#.

Diabetes, Jun; 67(6): 1079-1085 (2018)

... and featured in F1000

ADMP controls the size of Spemann's Organizer through a network of self-regulating expansion-restriction signals

Avi Leibovitz*, Hadas Kot-Leibowitz*, Danny Ben-Zvi, Abraham Fainsod.

BMC Biology. Jan 22; 16:13 (2018)

  ​

2012-2016

Local application of leptin antagonist attenuates Angiotensin II-induced ascending aortic aneurysm

Ben-Zvi D, Savion N, Kolodgie F, Simon A, Fisch S, Schäfer K, Bachner-Hinenzon N, Cao X, Gertler A, Solomon G, Kachel ET, Raanani E, Lavi Y, Kotev Emeth S, Virmani R, Schoen F, Schneiderman J.

Journal the American Heart Association. May 3;5(5). pii: e003474. (2016)

 

Angptl4 links adipose tissue triglyceride metabolism with alpha-cell proliferation

Ben-Zvi D, Brannadon O, Hadley S, Peterson Q, Blum B, Melton DA. 

PNAS. Dec 15, ;112(50):15498:503 (2015)

Modeling human nutrition using embryonic stem cells

Ben-Zvi D, Melton DA.

Cell. Mar 26;161(1):12-7 (2015)

Scaling Morphogen Gradients During Tissue Growth by a Cell Division Rule

Averbukh I*, Ben-Zvi D*, Mishra S*, Barkai N.

Development. June;141(10): (2014)

Scaling of Dorsal-Ventral Patterning in the Xenopus leavis Embryo

Ben-Zvi D, Fainsod A, Shilo BZ, Barkai N.

Bioessays. Feb;36(2):151-6 (2014)

Creating Gradients by Morphogen Shuttling.

Shilo BZ, Haskel-Ittah M, Ben-Zvi D, Schejter ED, Barkai N.

Trends in Genetics. Jan 28 (2013)

2008-2012

Glucose Metabolism: Key Endogenous Regulator of beta-cell Replication and Survival.

Dadon D, Tornovsky-Babaey S, Furth-Lavi J, Ben-Zvi D, Ziv O, Schyr-Ben-Haroush R, Stolovich-Rain M, Hija A, Porat S, Granot Z, Weinberg-Corem N, Dor Y, Glaser B.

Diabetes Obesity and Metabolism. Oct;14 Suppl 3:101-8 (2012)

Self-regulation of the head-inducing properties of the Spemann organizer

Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S.

PNAS. Sep 18 109(38):15354-9 (2012)

Self-organized Shuttling: Generating Sharp Dorsoventral Polarity in the Early Drosophila Embryo

Haskel-Ittah M, Ben-Zvi D, Branski-Arieli M, Schejter ED, Shilo BZ, Barkai N.

Cell. Aug 31;150(5):1016-28 (2012)

Scaling of Mophogen Gradients

Ben-Zvi D, Shilo BZ, Barkai N.

Current opinion in Genetics and Development. Dec; 21(6):704-10 (2011)

Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in the Drosophila Wing Imaginal Disc

Ben-Zvi D, Pyrowolakis G, Barkai N, Shilo BZ.

Current Biology. Aug 23 21(16):1391-6 (2011)

Scaling of Morphogen Gradients by an Expansion-Repression Integral Feedback Control
Ben-Zvi D, Barkai N.

PNAS. Apr 13 107(15):6924-9 (2010)

"Big Frog, Small Frog": Maintaining Proportions in Embryonic Development

Ben-Zvi D, Barkai N.

FEBS Journal. Mar;276(5):1196-207 (2009)

Scaling of the BMP Activation Gradient in Xenopus Embryos

Ben-Zvi D, Shilo BZ, Fainsod A*,Barkai N*.

Nature. Jun. 26: 453(1799):1205-11 (2008)