How can we generate more human gastric cell types in vitro?
Using our insights from the adaptation of the stomach to sleeve gastrectomy and our long interest in developmental biology, we are making gastric cell types in vitro from adult biopsies, and using them to study gastric physiology and endocrinology
What is the relationship between blood glucose and insulin secretion?
Insulin is secreted according the blood glucose levels. So we would expect that the insulin secretion rate would follow blood glucose levels. Right? Not exactly. We are measuring insulin secretion rate in healthy volunteers and in volunteers with type 2 diabetes to understand the relationship between glucose, insulin and insulin secretion rate.
When are foundation models useful for single cell RNAseq analysis
LLMs can do everything. Let's have them analyze our single cell data, and they will find fantastic stuff. Really? Together with IBM-Research, we benchmarked sc RNAseq foundation models and against classical linear methods, and found that without tinkering our fine tuning, foundation models are better than you standard linear models only when there is very few cells (e.g. analyzing epsilon cells in the pancreas...).
How do hormones reach the brain?
We think that changes in the biophysical properties of the fenestrated blood vessels that enable hormones such as leptin to enter the hypothalamus can explain hormonal imbalances that occur in pregnancy and obesity.
