What are the weight-loss Independent effects of bariatric surgery on the liver?

Many metabolic diseases such as type 2 diabetes and non alcoholic fatty liver are associated with obesity. We and others have found however that weight-loss induced by bariatric surgery improves the severity of these diseases also independent of weight-loss. Using patient data and mouse models we are figuring out which molecular pathways are affected by the surgery to improve disease independent of weight-loss, and trying to recapitulate surgery outcomes by applying these molecular handles.

What happens to the stomach after sleeve gastrectomy?

Sleeve gastrectomy is a common bariatric surgery where the stomach is cut so that it assumes the shape of a sleeve, connecting the oesophagus to the intestine. It is often reported that years after the surgery, the stomach expands and increases its volume. We would like to understand what drives gastric "regeneration" and whether the new stomach is the same as the original one at the molecular, cellular and physiological levels. 

How does bariatric surgery affect embryonic development?

Babies born to mothers who had bariatric surgery tend to be born at a lower weight. We are testing why bariatric surgery causes this effect, how to reverse it, and whether the altered maternal metabolism affects the embryonic and postnatal development of the pancreas.

Hormonal regulation over weight regain following diet/bariatric surgery

We found that mice homozygous to a cool hormone nearly do not gain weight after sleeve gastrectomy surgery on a high-fat diet and are normoglycemic. Sham-operated homozygous controls are as lean as sleeve operated heterozygotes. How does this hormone affect weight regain? What other neuroendocrine axes are involved? Can we learn something from surgery on normal weight regain and glycemic control?

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