Systems Physiology of Obesity and Metabolism
Hello! Shalom! Ahalan!
Our lab is curious about fundamental questions in obesity, metabolism, and metabolic diseases. How does the brain sense body composition? Why does the pancreas fail to secrete sufficient amounts of insulin in gestational and type 2 diabetes? What are the hidden roles of the stomach in systemic metabolism? Why does sleeve gastrectomy bariatric surgery lead to improvement in obesity metabolic diseases?? To answer these questions we collaborate closely with physicians, make use of mouse models, tissue biopsies, and organoids, and develop computational and mathematical tools to crystalize our ideas.
Our ultimate goal is to gain a basic understanding of normal physiological processes, and apply them to disease states.